Indoline Derivatives I: Synthesis and Factor Xa (FXa) Inhibitory Activities
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چکیده
منابع مشابه
Synthesis and evaluation of anthranilamide-based derivatives as FXa inhibitors
Factor Xa (FXa) plays a significant role in the blood coagulation cascade and is a promising target for anticoagulation drugs. Three oral FXa inhibitors have been approved by FDA for treating thrombotic diseases. In this study, 43 novel compounds were synthesized anthranilamide-based FXa inhibitors aiming to ameliorate the toxicity of traditional FXa inhibitors in clinic. The data indicated tha...
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INTRODUCTION Apixaban is an oral direct factor Xa inhibitor developed for the prophylaxis and treatment of thromboembolic disorders. Laboratory monitoring is not necessary, but the effects on common coagulation reagents and assays constitute clinically valuable information. OBJECTIVES To investigate the effects of apixaban on commonly used coagulation methods, and to evaluate anti-FXa assays ...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 2006
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.54.163